The Roman Empire

Italia, the strip between Italia and Greece on this map: https://en.wikipedia.org/wiki/Roman_province#/media/File:Augusto_30aC_-_6dC_55%25CS_jpg.JPG and Greece – with the Greek borders raised to Sofia in Bulgaria. All territory North of Sofia which hasn’t been assigned to other factions is largely occupied by the Hunnic Empire (their borders are unclear). Egypt is also Roman territory but Sardinia and Corse are owned by Carthage. Anatolia is owned by the Scaleson Caliphate (including Istanbul), east of them is the Persian Empire. The Path of Illyricum.

Plothooks for Rome
False Atlantis (Archaeological guild, tomb raiders). Barbarian invasions (Orcs mostly). Jewish slaves (historically accurate) and slaves from other places. Coliseum (collect monsters, fight in it). Tension between Greece and Rome. Suspected double agents. Tracking down Gods to add to the Pantheon (big goal). Dante’s Inferno (part of a quest to bring back a character, possibly Charlemagne because that was part of the Inferno).

Plothooks for Egypt
Tomb Raiding! Enough said? Also pirates a bit, raiders in the South, Saracens from the Middle-East, tribes coming from the south. Things here get extra-planar, Egypt seems perfect for that sort of thing. Also finding the source of the Nile, whoever does can direct its flow (it is currently flowing into Egypt from the Mediterranean Sea). The Library. Mummies/Liches.

Plothooks for Greece
Greek Mythology (Labyrinths, Hades, etc). Conflict between Greece and Italy/Turkey. Missions into Turkish territory. Roaming attackers from the Turks. Demigods roaming around, extremely interfering (but less powerful) Gods. The Medusa questline. Centaurs, Sartyrs, Nymphs, Dryads, Naiads, Nereids, etc. Ambrosia is believed to be what grant immortality, but only works on those with Divine Blood. Troy – Greece is separated into a loose alliance of city states/kingdoms that are allowed to war with each other? That’d mean that the events of Troy could spark a war with Turkey, which could be interesting.